ASSOCIATION OF 5q- AND REFRACTORY ANEMIA

Association of HLA-linked hemochromatosis with idiopathic refractory sideroblastic anemia.

Five of seven patients with idiopathic refractory sideroblastic anemia carried an HLA-A3 alloantigen (relative risk, 7.3; P = 0.02). The significance of this association was strengthened by study of two pedigrees. An abnormality in iron metabolism was found in two siblings who had an HLA-A3,B14 haplotype in common with the first proband. A second proband with idiopathic refractory sideroblastic...

Dyserythropoiesis , Refractory Anemia , and “

Twenty-one enzymatic activities and red cell glutathione content are compared in cord blood, dyserythropoietic disorders, normal subjects, and subjects with hemolytic syndromes and reticulocytosis approximating that of the newborn. The dyseryth ropoietic states are heterogeneous and include several hereditary disorders, “preleukemia” and overt leukemia, refractory anemia with and without marrow...

Dyserythropoiesis , Refractory Anemia , and “ Preleukemia : ”

Twenty-one enzymatic activities and red cell glutathione content are compared in cord blood, dyserythropoietic disorders, normal subjects, and subjects with hemolytic syndromes and reticulocytosis approximating that of the newborn. The dyseryth ropoietic states are heterogeneous and include several hereditary disorders, “preleukemia” and overt leukemia, refractory anemia with and without marrow...

Refractory megaloblastic anemia.

Iron-Refractory Iron Deficiency Anemia

Iron is essential for life because it is indispensable for several biological reactions, such as oxygen transport, DNA synthesis, and cell proliferation. Over the past few years, our understanding of iron metabolism and its regulation has changed dramatically. New disorders of iron metabolism have emerged, and the role of iron as a cofactor in other disorders has begun to be recognized. The stu...